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West Nile Fever Vaccine

Single-chain Fv-Fc fusion proteins protect against West Nile virus

Published in Vaccine Weekly, January 25th, 2006

Scientists have identified human single-chain Fv-Fc fusion proteins that protect against West Nile virus.

"West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infection. In this study, we identified a panel of 11 unique human single-chain variable region antibody fragments (scFvs) that bind the envelope protein of West Nile virus," investigators in the United States report.

"Selected scFvs were...

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