Apoptosis

LAQ824 and roscovitine induced apoptosis in human leukemia cells

Published in Vaccine Weekly, January 25th, 2006

Scientists found that coadministration of LAQ824 and roscovitine could induce apoptosis in human leukemia cells.

According to recent research published in the journal Molecular Cancer Therapeutics, "Reactive oxygen species; moreover, coadministration of the free radical scavenger N-acetylcysteine prevented LAQ824/roscovitine-mediated mitochondrial injury and apoptosis. Collectively, these findings suggest that combined treatment of human leukemia cells with LAQ824 and roscovitine disrupts maturation and synergistically induces apoptosis, lending further support for an antileukemic strategy combining novel histone deacetylase and cyclin-dependent kinase...

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Source: Vaccine Weekly (2006-01-25)

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