Adenovirus Vector

Method is developed to deliver adenovirus formulation to the lung

Published in Vaccine Weekly, February 1st, 2006

Scientists have developed a method for the aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter.

According to recent research published in the Journal of Gene Medicine, "Poor transduction of the ciliated airway epithelium and inefficient airway delivery of viral vectors are common difficulties encountered in lung gene therapy trials with large animals and humans. We delivered a helper-dependent adenovirus vector, incorporating a human epithelial cell-specific expression cassette, to rabbit lung."

"An intratracheal device was used to aerosolize a moderate dose of virus (5 x...

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Source: Vaccine Weekly (2006-02-01)

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