Rheumatoid Arthritis
Fiber modifications enhance gene delivery to arthritis synovium
Published in Vaccine Weekly, February 1st, 2006
"Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) do not express the coxsackie-adenovirus (Ad) receptor and are poorly permissive to Ad serotype 5 (AM). Genetically modified, coxsackie-Ad receptor-independent Ad5 vectors were studied for gene delivery in human RA FLS and synovium explants and murine collagen-induced arthritis. Short-fiber Ad5 vectors with seven fiber shaft repeats Ad5GFP-R7-knob, Ad5GFP-R7-arginine-glycine-aspartic acid (RGD) (RGD-liganded), and Ad5GFP Delta knob (knob-deleted) were compared with Ad5GFP-FiWT, a conventional...
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Source: Vaccine Weekly (2006-02-01)
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