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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . February 8th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccine - Anthrax spore vaccines based on toxin components have been developed

Chlamydia Vaccine - Vaccination of newborn mice protects against Chlamydia trachomatis

Diabetes Vaccine - Nasal vaccine against autoimmune diabetes has been developed

HIV/AIDS Vaccine - HIV-1 vaccine induces potent immune responses by needle-free intradermal delivery

Pertussis Vaccine - Study examined Bordetella pertussis antibody levels in children with asthma

Adenovirus Vector - Viral vector mitigates neutralization by antiviral antibodies

Allergy & Immunology - Immunotherapy for peanut allergy is getting closer to reality

Allergy & Immunology - Toll-like receptor ligands act as adjuvants in allergen-specific immunotherapy

Amyotrophic Lateral Sclerosis - Bcl-X L gene transfer is neuroprotective in models of motor neuron disease

Anthrax - Study shows no deaths in anthrax-infected animals when treated with BioThrax plus antibiotics

Atherosclerosis Vaccine - Apo B-100-related epitope reduces atherosclerosis and plaque inflammation

Avian Influenza - Bird flu infections in humans prompt new vaccine studies

Awards - U.S. NIH NIAID awards 2-year grant for development of influenza A virus vaccine

Bacteriology - Researchers determine a 'clonal' nature to Plasmodium falciparum

Bacteriology - Toll-like receptors are sentinels of host defense against bacteria

Baculovirus - Study characterized disassembly of structurally modified viral nanoparticles

Bordetella Vaccine - Mechanism of clearance of Bordetella from lungs requires TLR4

Breast Cancer - Epirubicin/paclitaxel compared with epirubicin/cyclophosphamide in breast cancer

Breast Cancer - Melatonin enhanced inhibitory effect of aminoglutethimide in breast cancer cells

Breast Cancer Vaccine - Livin may be a major breast cancer antigen

Cancer Therapy - Bioactive cyclic peroxides isolated from marine sponge Plakortis zyggompha

Cancer Therapy - Findings describe new data in cancer therapy research

Cancer Therapy - Novel benzopyridothiadiazepines identified as potential active antitumor agents

Cancer Therapy - Novel extracellular vesicles mediated anticancer drug resistance

Cancer Therapy - Novel flavonoid derivatives evaluated for anticancer activity

Cancer Therapy - Novel thermosensitive 5-fluorouracil-cyclotriphosphazene conjugates evaluated

Cancer Vaccines - Findings in cancer vaccines provide new insights

Cancer Vaccines - Researchers provide details of new studies and findings in the area of cancer vaccines

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Chickenpox Vaccine - Epidemiology of chickenpox is changing in Alberta

Chickenpox Vaccine - Lack of funding is limiting varicella vaccine coverage in Australia

Clinical Trials - Marketing application for investigational HIV protease inhibitor filed in Europe

Clinical Trials - Peg-Intron maintenance study in patients coinfected with hepatitis C and HIV initiated

Collaborations - Partnership signed to develop vaccine for hepatitis C

Contraceptive Vaccine - Adverse reactions to Freund's-adjuvanted immunocontraceptives were found in domestic cats

Cystic Fibrosis Therapy - Model for cystic fibrosis gene therapy has been developed

DNA Vaccine - CD4+ T cell-independent DNA vaccine shows promise against opportunistic infections

Dengue Vaccine - Recombinant yellow fever 17D-dengue type 2 virus shows promise for dengue fever vaccine

Diabetes Therapy - Hepatic insulin gene therapy prevents deterioration of vascular function

Diabetes Therapy - Researchers' data advance diabetes therapy research

Drug Development - Nitric oxide-donating aspirin induced apoptosis in human colon cancer cells

Drug Development - Sanofi pasteur makes milestone payment for bacterial vaccine development

Ebola Virus - Gene-specific therapies protect non-human primates from lethal disease

Finance - Biotech company closes $6 million financing and announces partnership for diabetes vaccine

Gastric Cancer - Anticancer drugs regulate peptide transporter 1 in gastric cancer cells

Gastric Cancer - ZD6474 inhibits gastric cancer tumor growth and intraperitoneal dissemination

Gene Delivery - Thermo-responsive polymers act as gene delivery vectors

Gene Delivery - Ultrasound is key factor in achieving nuclear DNA localization for gene delivery

Gene Therapy - AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy

Gene Therapy - Simian lentiviral vector provides stable transduction of monocytes

HIV/AIDS Prevention - Company signs partnership agreement with Clinton Foundation to supply HIV drugs

HIV/AIDS Prevention - Vaginal washing among African women increases risk of acquiring HIV-1

HIV/AIDS Testing - Developer announces selection of its HIV diagnostic test by Clinton Foundation

HIV/AIDS Therapy - IND for prevention of HIV receives fast tracks status from U.S. FDA

HIV/AIDS Vaccine - Cells from lentiviral-transduced CD34+ cells inhibited SHIV virus replication

HIV/AIDS Vaccine - Coreceptor-based anti-HIV strategy suppressed multiclade HIV-1 infections

HIV/AIDS Vaccine - HIV peptides in PLG microparticles enhance mucosal and systemic immune responses

HIV/AIDS Vaccine - Lack of awareness must be addressed to ensure adequate number of vaccine trial volunteers

HIV/AIDS Vaccine - Plasmid DNA and adenovirus vector with type 35 fiber protects against HIV

HIV/AIDS Vaccines - Recent studies add new data to HIV/AIDS vaccines research

HIV/AIDS Vaccines - Studies advance knowledge in HIV/AIDS vaccines research

Haemophilus Vaccine - Hib conjugate vaccine is less effective in HIV-infected African children

Head & Neck Cancer - Studies add new findings to head & neck cancer body of knowledge

Healthcare Coverage - New study finds employers fail to make cost-effective healthcare choices

Immunology - Cross-linking is needed for T cell co-stimulation activity of trimeric CD137L

Infectious Diseases - New web resource provides access to global health data by country and region

Infectious Diseases - Previous smallpox vaccination not associated with monkeypox disease severity

Influenza Vaccine - Adverse events are more likely when influenza vaccine is used inconsistent with labeling

Influenza Vaccine - GlaxoSmithKline biologicals submits first European pandemic influenza vaccine application

Influenza Virus - Report outlines EU regulations for eradication and control of poultry diseases

Leishmaniasis Vaccines - Findings describe new data in leishmaniasis vaccines research

Leukemia - Multiple myelomas and myeloid leukemias were sensitive to proteasome inhibitor I

Leukemia - Quercetin and trichostatin A exhibited cytotoxic effects in human leukemia cells

Liposomes - pH-sensitive peptide improves transfection efficiency of liposomes

Lung Cancer - Diallyl disulfide induced apoptosis in human A549 lung carcinoma cells

Lung Cancer - Docetaxel used to treat advanced non-small cell lung cancer

Lung Cancer - Gemcitabine compared to gemcitabine/carboplatin in non-small cell lung cancer

Lung Cancer - Safrole oxide induced apoptosis in A549 human lung cancer cells

Lung Cancer - Sesquiterpene lactones showed cytotoxicity against small cell lung cancer cell

Melanoma Vaccine - Study finds evidence for immunological tolerance against authochthonous melanomas

Melanoma Vaccines - Research in melanoma vaccines provides new insights

Meningitis Vaccine - Analysis of Neisseria meningitidis isolates reveals strains related to hypervirulent lineages

Meningitis Vaccine - Serogroup B Neisseria meningitidis vaccines are focus of review

Moneypox Risk Factors - Clinical characteristics of human monkeypox are the focus of review

Multiple Sclerosis Therapy - Inhibitor of alpha4 integrin suppressed allergic encephalomyelitis

Outbreak - Limited measles outbreak is reported in highly vaccinated U.S. boarding school

Pancreatic Cancer - Proteasome inhibitor MG132 induced apoptosis in human pancreatic cancer cells

Patents - U.S. patents granted relating to electroporation-enabled delivery of therapeutic molecules

Pediatric Vaccine - High proportion of children in Germany do not have adequate vaccine protection

Personnel - Dr. Raman Bedi joins oral healthcare company as senior consultant

Personnel - Pharmaceutical company appoints Matthew A. Wikler as chief medical officer

Pertussis Vaccine - Toxin inhibits neutrophil recruitment to delay B. pertussis clearance

Pharmaceutical Research - Center of Excellence in Infectious Disease and Biodefense launched

Pharmaceutical Research - Pharmacological study of tipifamib in advanced solid tumors conducted

Pneumococcal Vaccine - Invasive pneumococcal disease is declining in U.S. elderly

Pneumonia - Antibiotic resistance is returning pneumonia to a public health concern

Public Health - Monkeypox has re-emerged in the United States

Rabies Vaccine - Space-time cluster of adverse events is associated with canine rabies vaccine

Rectal Cancer - Oxaliplatin, capecitabine and external beam radiotherapy used in rectal cancer

Respiratory Syncytial Virus - Influenza isn't the only germ threat in winter

Rotavirus - Promise of Rotarix rotavirus vaccine discussed in major journal

Rotavirus - Published study finds Rotarix is effective against rotavirus disease in first year of life

Rotavirus - Vaccine prevented 98% of severe rotavirus gastroenteritis in infants

Rotavirus Vaccine - No link was found between rotavirus vaccine and intussusception in Honolulu

Rubella Vaccine - Matrix models for childhood infections have been applied to rubella and mumps

Smallpox Vaccine - Modified vaccinia virus Ankara protein acts with viral protein to block apoptosis

Smallpox Vaccine - Report describes adverse events linked to smallpox vaccine in U.S.

Smallpox Vaccine - Smallpox fusion proteins cross-react with neutralizing antibodies

Smallpox Vaccine - Vaccinia K1L protein mediates host-range function in RK-13 cells via ankyrin repeat

Tick-Borne Disease - Tick antigen vaccine controls Ixodes scapularis adult infestations

Tuberculosis Vaccine - BCG vaccine causes changes in peripheral blood T cell numbers in infants

Tuberculosis Vaccine - DNA vaccines against TB elicit efficient, protective immune responses

Tuberculosis Vaccine - Frequency of IFN-gamma-producing cells correlates with adjuvant enhancement of BCG vaccine

Tuberculosis Vaccine - Researchers examine strain-specific mycobacterial lipids and immunity to TB

Tuberculosis Vaccine - Vaccine induces cytokine responses in guinea pig model of pulmonary TB

Tuberculosis Vaccines - Recent findings illuminate research in tuberculosis vaccines

Typhoid Vaccine - Chinese typhoid vaccine appears effective

Vaccine Adjuvant - Low-toxicity MPL and RC529 are efficient adjuvants for CD4+ T cells

Vaccine Adjuvant - Melatonin finds use as vaccine agent

Vaccine Adjuvant - Rb1 fraction of ginseng elicits balanced Th1 and Th2 immune response

Vaccine Development - Mucosal effector memory T cells are focus of review

Vaccine Efficacy - Mucosal vaccines are improved by induction of innate immunity

Vaccine Efficacy - Report focuses on maximizing statistical power in group-randomized vaccine trials

Vaccine Vector - Method is developed to produce pseudotyped rAAV vectors using baculovirus expression system

Vaccine Vector - Study examined osmolality effect of serum-free media upon adenovirus production

Vaccines Vector - Studies advance knowledge in vaccines vector research

Vaccinia Virus Vaccine - Study examined substrate specificity of vaccinia virus thymidylate kinase

Vector Development - HSV-1 thymidine kinase delivered by HIV-based virus-like particles induced cell death

Vector Development - Polyomavirus EGFP-pseudocapsids introduce proteins and peptides into mammalian cells

Vector Development - Stable transgene expression is driven by promoter in HSV-1 vector

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