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Tuberculosis Vaccine

Vaccine induces cytokine responses in guinea pig model of pulmonary TB

Published in Vaccine Weekly, February 8th, 2006

Researchers have designed a vaccine that induces cytokine responses in a guinea pig model of pulmonary tuberculosis.

"Guinea pigs exposed to very small numbers of virulent tubercle bacilli by the respiratory route develop a disease which mimics many of the important features of the pathogenesis of human tuberculosis (TB), including the expression of strong protective immunity following vaccination with BCG. In order to elucidate the precise immunological mechanisms of vaccine-induced resistance in this model both mRNA and protein assays for several guinea pig cytokines and chemokines have been developed," investigators in the United States report.

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