Published in Vaccine Weekly, February 8th, 2006
"Guinea pigs exposed to very small numbers of virulent tubercle bacilli by the respiratory route develop a disease which mimics many of the important features of the pathogenesis of human tuberculosis (TB), including the expression of strong protective immunity following vaccination with BCG. In order to elucidate the precise immunological mechanisms of vaccine-induced resistance in this model both mRNA and protein assays for several guinea pig cytokines and chemokines have been developed," investigators in the United States report.
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