Gene Therapy
AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy
Published in Vaccine Weekly, February 8th, 2006
According to recent research from the United States, "Nerve growth factor (NGF) therapy has been proposed to treat cognitive impairments in aged patients including those with Alzheimer disease. Various viral vectors, including adeno-associated virus serotype 2 (AAV2), have been investigated for their ability to deliver NGF in brain. In this study, hybrid vectors (AAV2/5) consisting of the genome of recombinant AAV2 and the capsid of AAV serotype 5 were evaluated for their ability to deliver NGF and green fluorescent protein (GFP) genes into brain."
"Compared to...
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Source: Vaccine Weekly (2006-02-08)
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