Allergy & Immunology

Dendritic cells incubated with irradiated tumor cells enhance IFN-gamma and IL-4 production

Published in Vaccine Weekly, February 22nd, 2006

Dendritic cells incubated with irradiated tumor cells effectively stimulate T lymphocyte activation and induce enhanced expression of CD69, CD25 as well as production of IFN-gamma and IL-4.

According to a study from Slovenia, "Understanding of immunological processes at the molecular level in the cancer-bearing organism is the prerequisite for development of specific tumor vaccines. Most of these vaccines are aimed at enhancing the immunogenicity of the antigens presented by the tumor cells. Since dendritic cells (DC) are potent antigen-presenting cells (APC) in the organism, they are considered as a powerful tool to deliver the signals essential for the activation of...

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Source: Vaccine Weekly (2006-02-22)

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