Published in Vaccine Weekly, March 1st, 2006
Scientists in Spain report, "The spatial cell-material interaction remains a vital issue in forming biodegradable scaffolds in tissue engineering. In this study, to understand the influence of spatial architecture on cellular behavior, 2D and 3D chitosan scaffolds of 50-190 kD and >310 kD MW were synthesized through air drying and controlled rate-freezing/lypophilization technique, respectively. In addition, chitosan was emulsified with 19-, 76-, and 160-kD 50:50 poly lactide-co-glycolide (PLGA) using 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) as...
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