Drug Development
Diphtheria toxin-mediated antigen delivery into dendritic cells stimulates CD8+ T cells
Published in Vaccine Weekly, March 1st, 2006
According to a report from the United States, "Recognition and clearance of many intracellular pathogens requires the activation and subsequent effector functions of CD8+ T lymphocytes. To stimulate CD8+ T cells by immunization, the target antigens must be delivered into the cytosol of host cells. There they can be processed into peptides and presented in the context of major histocompatibility complex class I molecules to antigen-specific CD8+ T cells. One method of delivering antigens into the cytosol is to fuse them to modified bacterial toxins that are able to enter mammalian...
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Source: Vaccine Weekly (2006-03-01)
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