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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . March 8th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Cancer Vaccine - Anti-tumor DNA vaccines protect against tumor development

Herpesvirus Vaccine - HF10 lacks neuro-invasiveness and protects against herpes simplex virus

Plague Vaccine - Flagellin is effective adjuvant against Yersinia pestis

Smallpox Vaccine - Deletion of gene A41L enhances vaccinia virus vaccine efficacy

Allergy & Immunology - T-cell reaction indicates response to Th1-adjuvanted allergy vaccine

Alzheimer Disease Vaccine - Anti-A-beta-specific mAbs attenuate amyloid deposition in Alzheimer disease

Anthrax Vaccines - New data illuminates research in anthrax vaccines

Apoptosis - Intraperitoneal PTD-BIR3-RING inhibits apoptosis in ischemic brain

Avian Influenza - Technology for accelerating development of H5N1 flu vaccine enters pilot study

Bacteremia - Vaccine urgently needed for lethal bacterial disease

Bacteriology - Recent findings in bacteriology described

Bioterrorism - Multiferon antiviral studies with U.S. Army researchers using alpha interferon reported

Bioterrorism - Smallpox therapy development underway by BioFactura at University of Maryland bioprocess facility

Bladder Cancer - Bladder cancer inhibited by 1,1-bis(3'-indolyl)-1-(P-substitutedphenyl)methanes

Bladder Cancer - Histone deacetylase inhibitors modulate sensitivity of TRAIL-resistant bladder tumor cells

Breast Cancer - Anandamide inhibited adhesion and migration of breast cancer cells

Breast Cancer - Idarubicin displayed cytotoxic effect on breast cancer multicellular spheroids

Breast Cancer - Orathecin exhibited minimal clinical benefit in metastatic breast cancer

Breast Cancer - Reports advance knowledge in breast cancer research

Business Update - Immuno-pharmaceutical company targeting MS, HIV therapies announces new business strategy

Cancer Therapy - Antitumor benzothiazoles showed inhibitory activity against cancer cell lines

Cancer Therapy - COX-2 inhibition augments the efficacy of a cancer vaccine

Cancer Therapy - Irofulven cytotoxicity characterized in human cancer cells

Cancer Therapy - Method optimizes modification of carrier proteins with aminated haptens

Cancer Therapy - Studies add new findings to cancer therapy body of knowledge

Cancer Therapy - Tiron identified as bortezomib blocker

Cancer Vaccine - Antitumor efficacy of CD137 ligation is maximized by tumor vaccine

Cancer Vaccine - Chimeric DNA vaccine reverses morphine-induced immunosuppression and tumorigenesis

Cancer Vaccine - Commercial launch of telomerase-immortalized cell line through ATCC announced

Cancer Vaccine - H-2Db-specific CD8+ T-cell epitopes inhibit tumor growth

Cancer Vaccine - IL-2/liposome potentiates immune responses to cancer vaccine

Cancer Vaccine - Therapeutic cancer vaccines amplify tumor-specific regulatory T cells

Cancer Vaccine - Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses

Cancer Vaccines - Recent studies add new data to cancer vaccines research

Cervical Cancer - Gardasil, a cervical cancer vaccine, to receive priority review from the U.S. FDA

Cervical Cancer Vaccine - DNA vaccines carrying HPV16 E7 peptide protect against cervical tumors

Chagas Disease - Metacaspases of Trypanosoma cruzi are candidates for apoptosis mediators

Cholera Vaccine - Peptides mimicking Vibrio cholerae capsular polysaccharide elicit protective antibody response

Clinical Trials - HIV/AIDS vaccine trial launched in Entebbe, Uganda, as three-way collaborative effort

Collaborations - India-based pharma company enters joint venture to market antiretroviral products in South Africa

Colon Cancer - Effect of indomethacin on E-cadherin and beta-catenin expression in colon cancer studied

Colon Cancer - Induction of oxidative metabolism by mitochondrial frataxin may inhibit cancer growth

Colon Cancer - Oral uracil/ftorafur plus leucovorin treated metastatic colorectal cancer

Complementary & Alternative Medicine - Hydroxyanthraquinone compounds exhibited cancer inhibitory activity

Complementary & Alternative Medicine - Tuber lectin extract showed anti-cancer effect on human cancer cell lines

Contraceptive Vaccines - Researchers publish new studies and findings in the area of contraceptive vaccines

Drug Delivery - Transdermal drug delivery company introduces next generation skin permeation device

Drug Development - Dasatinib may affect neoplasms associated with gain-of-function KIT mutations

Drug Development - Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold developed

Drug Development - Phase I/II trial of typhoid fever vaccine initiated

Drug Resistance - Role of gamma-glutamyltransferase expression in cancer cells and drug resistance explored

Finance - Biotech company reports 2005 financial results

Finance - Collaboration with VRA expanded to include preliminary development of an influenza vaccine

Finance - Human therapeutics company reports stockholder loss of $18.6 million, or $0.52 per share

Food Safety - Project focuses on vaccines, tests for infectious animal diseases in food supply

Food Safety - Report describes Salmonella survey of Japanese layer farms

Foot-and-Mouth Disease Vaccine - Fungus extract enhances immunogenicity elicited by foot-and-mouth disease vaccine

Gastric Cancer - Biweekly irinotecan and cisplatin found effective in treating advanced gastric cancer

Gene Therapy - Reports advance knowledge in gene therapy research

Glioma Vaccine - EGFRvIII-derived CTL epitopes restricted by HLA A0201 are identified for glioma immunotherapy

Gliomas - Trichostatin A could be used to achieve tumor growth inhibition and cytotoxicity of gliomas

HIV/AIDS Diagnostics - Diagnostic tests company upgrades dry filter spot HIV-1 collection solution to monitor viral load

HIV/AIDS Research - New research reaffirms ability of TNX-355 to block HIV-1

HIV/AIDS Research - Study shows HIV patients respond well to Reyataz therapy

HIV/AIDS Therapy - Drug compound kills multiple HIV strains in in vitro lab test, researchers report

HIV/AIDS Vaccine - Replication-defective viruses safe and efficient for vaccines and vaccine vectors

HIV/AIDS Vaccine - Vaccination with adenovirus vectors elicited broad immunity to SIV

HIV/AIDS Vaccines - Reports add new data to HIV/AIDS vaccines research

HIV/AIDS Vaccines - Researchers publish new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS Vaccines - Studies advance knowledge in HIV/AIDS vaccines research

Hepatitis C Virus - HCV NS3 protein protects dendritic cells from recombinant virus expressing NS3

Hepatitis C Virus - HCV affects dendritic cell cytokine induction and T-cell stimulation

Human Papillomavirus Vaccine - Cervical mucosal antibodies protect against human papillomavirus 16

Human Papillomavirus Vaccine - HPV type 6 L2E7 vaccine fails to increase efficacy of conventional therapy

Human Papillomavirus Vaccine - HPV-16 peptide-specific immune responses reduce recurrence of cervical intraepithelial neoplasia

Human Papillomavirus Vaccine - Pap test results predict HPV status in young women

Influenza - Australian firm to apply for license to market influenza vaccine in the U.S.

Influenza - Blue Cross and Blue Shield of Florida offers influenza shots to seniors

Influenza Vaccine - New influenza vaccine takes weeks - not months - to mass produce

Influenza Vaccine - New recommendations take aim to improve influenza vaccination rates among healthcare workers

Influenza Vaccine - Vaccination against influenza in rheumatoid arthritis was not affected by disease-modifying drugs

Legal Issues - Fluvirin maker announces termination of SEC investigation

Leishmaniasis Vaccine -  Leishmania antigens that stimulate cellular immune responses have been identified

Leukemia - Combined treatment with BB-1 and TRAIL proposed as new cancer therapy strategy

Leukemia Vaccines - New findings in the area of leukemia vaccines described

Liver Cancer Vaccine - Dendritic cell vaccine and IL-12 result in autoimmune hepatic inflammation

Lung Cancer - Gemcitabine and cisplatin found effective in treating elderly patients with lung cancer

Lung Cancer - Gemcitabine used as first and second-line chemotherapy of lung cancer

Lung Cancer - Monitoring circulatory TBARs and SB could help prognosticate lung cancer

Lung Cancer Vaccine - Epidermal growth factor receptor induces T cell responses against lung cancer

Lymphoma - Phosphatidylinositol-3 kinase/Akt inhibition promoted apoptosis in Hodgkin lymphoma

Lymphoma Vaccine - IL-15 does not enhance efficacy of T cell lymphoma vaccine

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

Malaria Vaccines - Reports add new data to malaria vaccines research

Malaria Vaccines - Researchers describe findings in malaria vaccines studies

Malaria Vaccines - Studies advance knowledge in malaria vaccines research

Medulloblastomas - Antiproliferative and radiosensitizing effects of CAPE for medulloblastoma shown

Melanoma - Paclitaxel and carboplatin were combined to treat metastatic melanoma

Melanoma Vaccine -  Listeria vaccine elicited central nervous system tumor immunity

Melanoma Vaccine - Allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 has been developed

Melanoma Vaccine - CCL21 adjuvant enhances immunogenicity of DNA melanoma vaccine

Melanoma Vaccine - Dendritic cell vaccine induces CD8+ T cell responses against NA17-A2 tumor peptide

Melanoma Vaccines - Studies add new findings to melanoma vaccines body of knowledge

Meningitis - Intimate kissing quadruples risk of meningitis in teenagers

Meningococcal Vaccine - Researchers present strategies to manage a cluster of meningococcal diseases

Molecular Diagnostics - Data highlighting the role of molecular diagnostics presented at major HIV/AIDS meeting

Multiple Myeloma Vaccine - Adenoviral-mediated gene transfer results in cytotoxicity of multiple myeloma cells

Multiple Sclerosis Therapy - Bone marrow transplant plus gene therapy ameliorates encephalomyelitis

Multiple Sclerosis Vaccine - Intradermal DNA vaccines encoding for T-cell receptors show promise for multiple sclerosis

Osteosarcomas - Use of cisplatin in metastatic osteosarcoma justified despite toxicity

Parkinson Disease - Recent findings in Parkinson disease provide new insights

Pediatric Cancer Therapy - Methodology presented for quantification of Act-D and VCR in pediatric cancers

Pertussis Vaccines - Researchers provide details of new studies and findings in the area of pertussis vaccines

Pharmacology - Efficacy of depsipeptide in childhood cancer models studied

Pneumococcal Disease - Antibodies to CbpA and Ply may protect children against pneumococcal colonization

Pneumococcal Vaccine - Study examined Streptococcus pneumoniae serotypes in Brazilian children

Pneumonia Vaccine - IgA modulates inflammatory responses in pneumonia in vitro model

Product Licensing - U.S. FDA licenses vaccine to protect infants against rotavirus infection

Prostate Cancer - Induction of apoptosis by 2-ME and paclitaxel in prostate cancer discussed

Prostate Cancer - Inosine 5'-monophosphate dehydrogenase inhibitors used to manage prostate cancer

Prostate Cancer - NaBu proposed as chemopreventive agent for prostate cancer

Prostate Cancer Vaccines - New findings in the area of prostate cancer vaccines described

Proteomics - Glutaredoxin 2 affinity tag for peptide and protein purification has been developed

Proteomics - Recovery of interferon alpha 2b from E. coli inclusion bodies has been optimized

Proteomics - Researchers optimized overexpression of glutamate mutase S component

Public Health - Pneumococcal vaccine in children decreases pneumococcal disease in HIV+ adults

Rotavirus Gastroenteritis - U.S. FDA approves Rotateq to prevent a leading cause of severe infant diarrhea

Rotavirus Vaccine - Review examines risks and benefits of rotavirus vaccines in Latin America

Smallpox Vaccine - Self-assessment of skin reaction is valid after smallpox vaccination

Soft Tissue Sarcomas - ET-743 proposed as novel agent with activity in soft tissue sarcomas

Staphylococcus Vaccine - Protein A triggers supraclonal B-cell responses upon Staphylococcus infection

Tick-Borne Disease -  Boophilus microplus yolk pro-cathepsin shows promise for anti-tick vaccines

Toxoplasmosis Vaccine - Study characterized antibodies against Toxoplasma gondii MIC2 protein

Transplant Medicine - Article examines immunity for tumors and microbes after autotransplantation

Tuberculosis Diagnosis - Researchers publish new studies and findings in the area of tuberculosis diagnosis

Tuberculosis Vaccines - Recent studies add new data to tuberculosis vaccines research

Tuberculosis Vaccines - Texas, Brazilian scientists collaborate on TB vaccine

Typhus Vaccines - Studies advance knowledge in typhus vaccines research

Vaccine Adjuvants - CpG oligodeoxynucleotides function as effective adjuvant in aged mice

Vaccine Adjuvants - CpG-rich DNA suppresses T cell immunity via induction of IDO

Vaccine Delivery - Lipid emulsions increase transgene expression in hepatocytes after adenoviral transfer

Vaccine Development - Method to generate antibody against human protein SNEV has been developed

Vaccine Development - Phase I shows escalating doses of S. epidermidis and S. aureus vaccines are well-tolerated

Vaccine Efficacy - Inserting antigenic protein in flagellin improves Th1 immune response

Vaccines Vector - Researchers' work adds to vaccines vector body of knowledge

Vector Development - Binary AdEasy vector systems use Tet-regulated transgene expression

Vector Development - Findings describe new data in vector development research

Vector Development - High expression levels of alpha 1-antitrypsin are mediated by adeno-associated virus

Vector Development - New findings in the area of vector development described

Vector Development - New findings in vector development described

Virology - Genital human papillomavirus infection in men is focus of review

Virology - Study analyzed human respiratory syncytial virus phosphoprotein

Virology - Study examined genetic stability of dengue vaccine candidates

Virology - Study investigated porcine reproductive and respiratory syndrome virus vaccine

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