Prostate Cancer

Induction of apoptosis by 2-ME and paclitaxel in prostate cancer discussed

Published in Vaccine Weekly, March 8th, 2006

Scientists discussed the induction of apoptosis by 2-methoxyestradiol (2-ME) and paclitaxel in prostate cancer.

According to a study from the United States, "2-ME is an endogenous metabolite of estradiol with promise for cancer chemotherapy, including advanced prostate cancer. We have focused on events related to cell cycle arrest (G1 and G2/M) and induction of apoptosis in human prostate cancer cells."

"Treatment with 2-ME increased cyclin B I protein and its associated kinase activity followed by later inhibition of cyclin A-dependent kinase activity and induction of apoptosis. Similar results were obtained with paclitaxel (taxol), a clinically...

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Source: Vaccine Weekly (2006-03-08)

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