Vaccine Adjuvants
CpG oligodeoxynucleotides function as effective adjuvant in aged mice
Published in Vaccine Weekly, March 8th, 2006
According to a study from Argentina, "During aging, there is an increased rise in susceptibility to infectious diseases. However, it is still unresolved whether standard vaccine adjuvants are efficient in the elderly."
"We report that immunization with OVA plus synthetic oligodeoxinucleotides containing immunostimulatory CpG motifs (CpG-ODN) stimulates specific Th1 response in aged mice," said Belkys Angelica Maletto and colleagues at the Universidad Nacional de Cordoba. "The immunization with OVA/CpG-ODN induced an increase in CD19+ cells. These cells from aged mice in...
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Source: Vaccine Weekly (2006-03-08)
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