Vector Development
Binary AdEasy vector systems use Tet-regulated transgene expression
Published in Vaccine Weekly, March 8th, 2006
According to researchers in Sweden, "We describe the construction of a set of binary adenovirus vectors encoding for a tetracycline-regulatable expression cassette and the Tet-ON or the Tet-OFF transcriptional activator proteins from a single viral chromosome."
Saideh Berenjian and Goran Akusjarvi at the University of Uppsala explained, "The rabies virus glycoprotein was cloned into the El region and the tetracycline activator proteins were inserted in both orientation in place of the E3 region. To further restrict background...
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Source: Vaccine Weekly (2006-03-08)
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