Vector Development
High expression levels of alpha 1-antitrypsin are mediated by adeno-associated virus
Published in Vaccine Weekly, March 8th, 2006
According to researchers in the United States, "Alpha 1-antitrypsin (alpha 1AT) deficiency is a genetic disorder causing emphysema if serum alpha 1AT levels are <570 mcg/mL. We have shown that intrapleural administration of an AAV5 alpha 1AT vector yielded persistent therapeutic alpha 1AT serum levels."
"Since anti-AAV2 and -AAV5 antibodies prevalent in humans may limit the use of these common serotypes in gene therapy, we screened 25 AAV...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
Source: Vaccine Weekly (2006-03-08)
More Articles from Vaccine Weekly
- Cancer Vaccine
Anti-tumor DNA vaccines protect against tumor development - Herpesvirus Vaccine
HF10 lacks neuro-invasiveness and protects against herpes simplex virus - Plague Vaccine
Flagellin is effective adjuvant against Yersinia pestis - Smallpox Vaccine
Deletion of gene A41L enhances vaccinia virus vaccine efficacy - Allergy & Immunology
T-cell reaction indicates response to Th1-adjuvanted allergy vaccine - Alzheimer Disease Vaccine
Anti-A-beta-specific mAbs attenuate amyloid deposition in Alzheimer disease - More from this issue of Vaccine Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
