Smallpox Vaccine

Deletion of gene A41L enhances vaccinia virus vaccine efficacy

Published in Vaccine Weekly, March 8th, 2006

Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

"Vaccinia virus (VACV) is the vaccine that was used to eradicate smallpox and is being developed as a recombinant vaccine for other pathogens. Removal of genes encoding immunomodulatory proteins expressed by VACV may enhance virus immunogenicity and improve its potential as a vaccine," investigators in England report.

"Protein A41 is a candidate for removal, having sequence similarity to the VACV chemokine-binding protein, vCKBP, and an association with reduced inflammation during dermal infection. Here, it is shown that, at low doses, VACV strain Western Reserve (WR)...

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Source: Vaccine Weekly (2006-03-08)

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