Published in Vaccine Weekly, March 8th, 2006
Study 1: Research from the United States has reported that transduction of mouse bone marrow-derived dendritic cells (DC) is enhanced by repetitive infection with self-complementary adeno-associated virus (AAV) 6 combined with immunostimulatory ligands.
"The potential of AAV-based vectors in human gene therapy is being explored for several diseases. Although sustained transgene expression and low vector-associated cellular immunity are attractive features of recombinant (r) AAV, the wider application of rAAV vectors encapsidated in serotype 2 capsid is hampered by...
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