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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . March 29th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Plague Vaccine - Plague is protected against by Yersinia pestis antigens expressed in plants

Rotavirus Vaccine - Ricin toxin B subunit-rotavirus NSP4 fusion protein stimulates Th1 response

Schistosomiasis Vaccine -  Schistosoma japonicum paramyosin fragments were effective in mice

Schistosomiasis Vaccine - Genes expressed in lung schistosomulum of Schistosoma mansoni are identified

Smallpox Vaccine - Monkeypox virus infection is more effectively treated with antivirals than with smallpox vaccine

Amebiasis Vaccine - Amebiasis vaccine progress is reviewed

Anthrax Vaccines - Findings advance knowledge in anthrax vaccines research

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Apoptosis - Triphala proposed as novel anticancer drug

Avian Influenza - Baxter receives contract from U.K. to produce stockpile of H5N1 flu vaccine

Avian Influenza - DelSite and Invitrogen Corp. ink avian H5 influenza nasal vaccine agreement

Avian Influenza - Delivery expectation for U.S. government H5N1 vaccine stockpile contract updated by Chiron

Avian Influenza - Generex Biotechnology to present pandemic influenza vaccine program at Bird Flu Summit

Avian Influenza - Sanofi pasteur supplies avian flu pre-pandemic vaccine to Italian Ministry of Health

Bioterrorism - VaxGen, BD to evaluate micro dermal injection technology for anthrax vaccine delivery

Breast Cancer - Research add new data to breast cancer body of knowledge

Business & Finance - Cerus Corp. reports $5.6 million in Q4 revenues

Business & Finance - Generex Biotechnology receives $11 million from warrant exercises

Cancer Therapy - Research add new data to cancer therapy body of knowledge

Cancer Therapy - Targeting cell-impermeable prodrug activation to tumor microenvironment reduced drug toxicity

Cancer Vaccine - Anaplastic lymphoma kinase is antigen for immune interventions

Cancer Vaccine - Anti-HER2/neu IgG3 fusion proteins promote dendritic cell presentation

Cancer Vaccine - Anti-HER2/neu cytokine fusion proteins plus antigen protects against HER2/neu-expressing tumors

Cancer Vaccine - Antitumor responses can be targeted using attenuated Listeria

Cancer Vaccine - Cancer vaccine's effects depend on blocking CTLA-4 signaling

Cancer Vaccine - Glioma antigen is identified using cytotoxic T lymphocytes induced by HSV cancer vaccine

Cancer Vaccine - Tumor antigen that plays key role in immunomodulation is blocked by antibodies

Cancer Vaccine - Tumor cells transduced with MHC II transactivator and CD80 activate tumor-specific CD4+ T cells

Cancer Vaccine - Tumor vaccine is enhanced by Ig attachment to dendritic cell proteins

Cancer Vaccine - Vaccine therapy is achieved by genetic modification of dendritic cells

Cancer Vaccines - Findings in cancer vaccines provide new insights

Cancer Vaccines - Recent studies add new data to cancer vaccines research

Cancer Vaccines - Research add new data to cancer vaccines body of knowledge

Cancer Vaccines - Research in cancer vaccines provides new insights

Cancer Vaccines - Researchers publish new studies and findings in the area of cancer vaccines

Clinical Trials - Genitope Corporation initiates clinical trial to evaluate MyVax Personalized Immunotherapy

Collaborations - Novavax announces strategic alliance with PacificGMP on pandemic influenza vaccine

Colorectal Cancer - 5-fluorouracil inhibited cytochrome P4502C9 activity in cancer patients

Complementary & Alternative Medicine - Catechin compounds recovered from Korean tea by solvent extraction

Complementary & Alternative Medicine - Putative mechanism for anticancer properties of plant polyphenols proposed

Cytomegalovirus -  Peromyscus cytomegalovirus expressing hantavirus glycoprotein was examined

DNA Research - DNA vaccination at multiple sites enhances immune responses in mice

Dengue Fever Vaccine - Dengue infection's effects in dendritic cells were examined

Diagnostics - Medical Services begins shipping VScan HIV test kit to Egypt

Disease Control - Compulsory vaccination and conscientious exemptions are examined

Disease Control - European Medicines Agency receives second application for human pandemic influenza vaccine

Disease Control - Tuberculosis management in children in low-income countries is examined

Drug Delivery - Tumor cell adhesion and packing density contributed to drug resistance

Drug Development -  M. tuberculosis in adjuvant modulates the Th immune response balance

Drug Development - 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan identified as novel anticancer agent

Drug Development - Cervical cancer apoptosis was induced by 3 beta-hydroxy-12-oleanen-27-oic acid

Drug Development - Cytotoxicity of isoxazolidinyl polycyclic aromatic hydrocarbons examined

Drug Development - European regulatory authorities approve Glaxo SmithKline's Rotarix rotavirus vaccine

Drug Development - Gamma-retroviral and lentiviral SIN vectors are equally potent

Drug Development - Gene therapy may be aided by foamy virus vectors

Drug Development - Immunoadjuvant activity is linked to chaperoning function of stress protein

Drug Development - Miliusanes proposed as potential anticancer agents

Drug Development - N-(7-indazolyl)benzenesulfonamide derivatives identified as potent cell cycle inhibitors

Drug Development - Novel potential anticancer naphthyl phosphoramidites of BvdU studied

Drug Development - Polyethylene imine grafted to poly(ethylene glycol)-like core shows promise for gene delivery

Drug Development - Potential cancer chemopreventive activity of isoquinolines analyzed

Drug Development - Promising anticancer agents discovered

Drug Development - Quindoline derivatives identified as promising agents for cancer treatment

Drug Development - Synthesis and antitumor activity of platinum acetonimine complexes described

Drug Development - Tumor antigen-specific CD8+ memory T cells are induced by lentivectors

Endometriosis Therapy - BCG vaccine inhibits peritoneal endometriotic implants in rat model

Epidemiology - Reducing pertussis transmission causes disease resurgence

Epidemiology - Rotavirus gastroenteritis is effectively controlled by universal vaccination

Epidemiology - Rubella can be spread by nonvaccinated adult men

Finance - Cerus Corp. announces proposed public offering of common stock

Finance - MorphoSys AG announces revenues for the year 2005 of EUR 33.5 million

Finance - Nabi Biopharmaceuticals announces decrease in annual revenues

Finance - Novavax announces revenues for fourth quarter were $2.2 million

Finance - VaxGen to raise $27 million through sale of common stock in private placement

Food-Borne Illness - Staph infections in dairy cattle are not eliminated by vaccination and antimicrobials

Gene Therapy - Studies add new findings to gene therapy body of knowledge

Glioma Cells - Intracellular signaling pathways were involved in inhibition of glioma cells by melatonin

Guillain-Barre Syndrome -  Campylobacter jejuni LOS carbohydrate mimicry is critical for neuropathy

HIV/AIDS Facilities - Baylor-Bristol-Myers Squibb children's HIV/AIDS medical center opens in Swaziland, Africa

HIV/AIDS Vaccine - Dendritic cells from HIV-infected patients partially reconstitute CD4 T-cell responses

HIV/AIDS Vaccine - HIV-1 subtype B third variable region peptide motifs have been analyzed

HIV/AIDS Vaccine - HIV-1 was protected against by gp41 region fused with retrovirus fragment

HIV/AIDS Vaccine - Standardized antiretroviral regime is needed for HIV vaccine trial subjects who seroconvert

HIV/AIDS Vaccines - Findings describe new data in HIV/AIDS vaccines research

HIV/AIDS Vaccines - New findings in the area of HIV/AIDS vaccines described

Hepatitis C Virus - HCV refractory T cell response is activated by ablation of hydrophobic domains

Herpes Vaccine - HSV protection and humoral immunity are enhanced by DNA priming-protein

Human Papillomavirus Vaccine - Cervical cancer vaccines are focus of review

Human Papillomavirus Vaccines - New findings in the area of human papillomavirus vaccines described

Immunotherapy - Function of immunoglobulin A in immunity is focus of review

Influenza Vaccine - Chiron inks pandemic influenza vaccine contract with the U.K. government

Influenza Vaccine - In chronic obstructive pulmonary disease, inactivated influenza vaccine reduces exacerbations

Influenza Vaccine - Influenza protective and nonprotective T cell epitopes have been identified

Influenza Vaccine - Influenza vaccination factors among elderly in Brazil are focus of report

Leukemia - Research in leukemia provides new insights

Leukemia - Researchers' findings advance leukemia research

Leukemia Vaccine - Antileukemia response is elicited by beta-defensin 2-transduced leukemic cells

Lung Cancer - Lung cancer cell growth was inhibited by quercetin glucuronides

Lung Cancer - Researchers' findings advance lung cancer research

Lung Cancer - Studies advance knowledge in lung cancer research

MMR Vaccines - Findings describe new data in MMR vaccines research

Malaria Therapy - Trial of intermittent malaria treatment in children reduces cases by 86%

Malaria Vaccine - Cellular immunity against malaria is linked to P7 and P8 orientation in MHC-peptide-TCR complex

Malaria Vaccine - Malaria vaccine development is aided by adjuvants that induce CD4 memory

Malaria Vaccines - New findings in malaria vaccines described

Melanoma - Melanoma could be treated by oridonin

Melanoma Vaccine - In melanoma, antibody SM5-1 recognizes expression of fibronectin variant

Melanoma Vaccines - Researchers provide details of new studies and findings in the area of melanoma vaccines

Melanoma Vaccines - Researchers report details of new studies and findings in the area of melanoma vaccines

Meningitis Vaccine -  H. influenzae type b polysaccharide production is improved

Meningococcal Vaccine - Group B meningococci are protected against by anti-idiotypic DNA vaccine

Oral Squamous Cell Carcinoma - Oral squamous cell carcinoma apoptosis was induced by safingol

Ovarian Cancer - MRP2 expression did not correlate with chemotherapy response in ovarian cancer

Ovarian Cancer - Proteomics profile changes in cisplatin-treated ovarian cancer cells analyzed

Pancreatic Cancer - Studies add new findings to pancreatic cancer body of knowledge

Patents - Cel-Sci gets U.S. patent for use of L.E.A.P.S. vaccine technology

Patents - Millenia Hope acquires pending patent describing compounds that inhibit HIV-1 RNase_H

Pediatrics - Influenza vaccination rates are low in older asthmatic children with Medicaid

Personnel - Fredrick D. Cobb appointed vice president of finance at Advaxis

Pneumococcal Vaccine - Bacteremic pneumococcal pneumonia in adults is reduced by pediatric pneumococcal vaccination

Prostate Cancer - Recent studies add new data to prostate cancer research

Prostate Cancer Vaccine - Prostate cancer vaccine encoding prostatic acid phosphatase was safe and immunogenic in rats

Proteomics - CHO production host DG44 and derivative recombinant cell lines have been characterized

Proteomics - New findings in the area of proteomics detailed

Rotavirus Vaccines - Researchers publish new studies and findings in the area of rotavirus vaccines

Shingles Vaccine - U.S. FDA review date for Merck's investigational shingles vaccine extended

Smallpox Vaccine - Diluted Lister strain vaccinia virus vaccine is effective against smallpox

Smallpox Vaccine - Most adverse reactions in smallpox vaccine recipients were short-term

Smallpox Vaccine - Orthopoxvirus infection was partially protected against by enveloped virus protein

Solid Cancers - Patients with solid cancers could be treated by 7-hydroxystaurosporine and topotecan

Tuberculosis Risk Factors - Positive tuberculosis skin test risk factors in Swiss children were studied

Tuberculosis Vaccine - Immunity against tuberculosis is induced by extraordinarily few organisms of live BCG vaccine

Tuberculosis Vaccine - Tuberculosis vaccine quest is focus of review

Tuberculosis Vaccine - Tuberculosis vaccine safety is focus of discussion

Urothelial Tract Tumors - High-dose intensity M-VAC reduced risk of progression of urothelial tract tumors

Vaccines Delivery - New findings in the area of vaccines delivery described

Vector Development - New research in the area of vector development detailed

Virology - Antiviral protection by neonate CD8+ memory cells rivals adult memory cells

Virology - HIV-1 replication is reduced by decreasing frameshift efficiency

Virology - HPV L2 structural protein localization is influenced by cellular factors

Virology - Researchers detail new studies and findings in the area of virology

Virology - Vaccinia virus A35R protein and role in virulence have been characterized

Virology - Vaccinia virus entry requires cysteine-rich membrane protein encoded by A16L gene

Virology - Wild-type hepatitis A virus has been stably grown in cell culture

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