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Cancer Vaccines

Research in cancer vaccines provides new insights

Published in Vaccine Weekly, March 29th, 2006

Reports from France, Italy and Austria highlight recent research on cancer vaccines.

Study 1: Dendritic cells were essential for priming but inefficient for boosting antitumor immune response in an orthotopic murine glioma model.

Investigators in France report, "The prognosis of malignant gliomas remains dismal and alternative therapeutic strategies are required. Immunotherapy with dendritic cells (DCs) pulsed with tumor antigens emerges as a promising approach. Many parameters influence the efficacy of DC-based vaccines and need to be optimized in preclinical models. The present study compares different vaccine schedules using DCs loaded with tumor...

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