Cancer Vaccines
Studies add new findings to cancer vaccines body of knowledge
Published in Vaccine Weekly, April 5th, 2006
Study 1: OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen.
According to investigators in the United States, "T cell costimulation via OX40 is known to increase CD4+ T cell expansion and effector function and enhances the development of T cell memory. OX40 costimulation can also prevent, and even reverse, CD4+ T cell anergy. However, the role of OX40 in CD8+ T cell function is less well defined, particularly in the setting of immune tolerance."
"To determine the...
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Source: Vaccine Weekly (2006-04-05)
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