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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . April 12th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccine - Anthrax mucosal and systemic immunities are induced by nasal immunization

Avian Disease - Single dose of avian pneumovirus confers long-lasting immunity

Encephalitis - Encephalitis protection is conferred by immunization with recombinant adenovirus

Epidemiology - Booster vaccination effects on disease epidemiology have been modeled

Transplant Medicine - Orthotopic liver transplantation can precede live virus immunization

Adverse Drug Reaction - BCG vaccination is linked to septic dislocation of the hip

Adverse Drug Reaction - Chiron recalls, withdraws Morupar MMR vaccine from Italian and developing world markets

Allergy & Immunology - B cell-induced lymphangiogenesis mobilizes dendritic cells

Amyloid Fibrils - Physiological factors affecting beta2 -microglobulin amyloid formation are documented

Apoptosis - Polyphenols purified from the aroeira plant induced apoptosis in DU145 cells

Apoptosis - Role of annexin A5 imaging in cancer treatment and surveillance explored

Apoptosis - Schisandrin B enhanced doxorubicin-induced apoptosis of cancer cells

Apoptosis - Studies add new findings to apoptosis body of knowledge

Autoimmune Disease - Osteopontin-CD44 pathway does not participate in development of autoimmune myocarditis

Avian Influenza - Recombinomics urges release of H5N1 avian influenza sequences from WHO private database

Avian Influenza - U.S. Department of Health orders 1.75 million more courses of anti-viral zanamivir Relenza

Breast Cancer - Findings advance knowledge in breast cancer research

Breast Cancer - Studies add new findings to breast cancer body of knowledge

Business & Finance - Enzo Biochem reports second quarter results, HIV-1 Stealth Vector trial initiated

Cancer Therapy - Studies add new findings to cancer therapy body of knowledge

Cancer Vaccines - Findings advance knowledge in cancer vaccines research

Cancer Vaccines - Researchers provide details of new studies and findings in the area of cancer vaccines

Cancer Vaccines - Researchers' work adds to cancer vaccines body of knowledge

Cholera Toxin - Cholera toxin induces immunomodulator transcriptional responses

Clinical Trials - Samaritan starts second phase 2 monotherapy trial of oral anti-viral agent in HIV patients

Colorectal Cancer - Chemotherapy-induced colorectal cancer cell death inhibited by c-FLIP

Colorectal Cancer - Colorectal cancer did not show objective response when treated with capecitabine and thalidomide

DNA Research - Two-step red-mediated recombination allows DNA manipulation in Escherichia coli

DNA Vaccine - DNA vaccine encoding Der p2 allergen down-regulates STAT6 expression

Drug Delivery - Cationic liposomes are promising in drug and gene delivery

Drug Development - Corroles are specifically delivered to tumor cells via noncovalent conjugates

Drug Development - Intravenous delivery of plasmid DNA generates antibody

Drug Development - Simplified ecteinascidin-saframycin analogs synthesized

Drug Development - Stilbenoids of Kobresia nepalensis exhibited DNA topoisomerase II inhibition

Drug Development - Structural basis for antitumor effect of aplyronine A studied

Drug Development - Wyeth Pharmaceutical's form of antibiotic tigecycline gets 'positive opinion' in Europe

Drug Discovery - CytRx provides 2006 update on RNAi-based drug-discovery programs

Ebola Vaccine - A paramyxovirus-vectored vaccine protects against a lethal-dose Ebola virus challenge

Esophageal Tumors - Hypoxic esophageal tumors responded to radiotherapy with addition of irinotecan

Finance - Dynavax reports fourth-quarter and year-end results close to previous year

Finance - Iomai receives second payment of $2.9 million NIH grant for pandemic flu vaccine research

Finance - Point Therapeutics reports a net loss of $5,899,000 for fourth quarter

Finance - Progenics Pharmaceuticals reports fourth quarter revenues were $2 million

Gene Therapy - Cationic gene delivery polymer has been synthesized and characterized

Gene Therapy - Uronic acid functionalized copolymers can be synthetic gene carriers

Gene Therapy - Viral vectors activate endothelial cell signal transduction

Gene Transfer - LYVE-1 cDNA delivery creates blocking antibodies

Genetics & Genomics - Mycobacterial vaccination and infection induces transcriptional responses

HIV/AIDS Diagnostics - IFN-gamma alone may be insufficient to evaluate breadth of HIV-specific T cell response

HIV/AIDS Evolution - HIV-1 env evolves toward ancestral states upon transmission to a new host

HIV/AIDS Research - U.S. NIH to initiate testing of Mymetics' HIV-AIDS mucosal prophylactic vaccine candidate

HIV/AIDS Vaccine - Fusion molecules could be the key to producing vaccines from plants

HIV/AIDS Vaccine - Juvaris receives SBIR Advanced Technology NIH-funded grant for HIV vaccine development

HIV/AIDS Vaccine - Novavax receives additional government funding for HIV/AIDS vaccine research

HIV/AIDS Vaccine - Peptide epitope of neutralizing HIV-1 antibody 4E10 analyzed

Head & Neck Cancer - Head and neck squamous cell carcinoma treated by docetaxel, cisplatin, and 5-fluorouracil

Health Promotion - Survey reveals percentage of parents don't trust government advice on vaccine safety

Healthcare Coverage - Del. Brown's bill to ensure access to cervical cancer screening passes West Virginia legislature

Hepatocellular Carcinoma - Hepatocellular carcinoma treated by menatetrenone, a vitamin K2 analog

Herpes Simplex Virus - Treatment of intravaginal HSV-2 infection is aided by mucosal innate activation

Human Papillomavirus - Human papillomaviruses are genotyped by bead-based multiplex method

Human Papillomavirus - Study group urges establishment of international standard for HPV 16 antibodies

Human Papillomavirus Vaccine - Dendritic cell activation by HPV-16 vaccine involves a specific C-type lectin

Hyperthyroidism - Induced Graves' hyperthyroidism is improved by adenovirus-encoded thyrotropin receptor

Immunotherapy - Connective tissue disease is induced with U1 small nuclear RNP autoantigen

Immunotherapy - Heat labile Escherichia coli enterotoxin is potential adjuvant for transcutaneous cancer immunotherapy

Immunotherapy - Mirus Bio announces efficient new genetic immunization method to produce antibodies

Immunotherapy - Study to determine how to protect patients with weakened immune systems from influenza

Immunotherapy - T cell crosspriming in epithelial tissues is determined by dendritic cells

Immunotherapy - T cell-mediated oral tolerance is intact in germ-free mice

Influenza Vaccine - Master donor virus for live attenuated influenza vaccines has been genetically mapped

Influenza Vaccine - Microbix technology yields significant increase in influenza virus for vaccine production

Leukemia - Adult T cell leukemia treated by curcumin

Leukemia - New findings in the area of leukemia described

Lung Cancer - Lung cancer treated by carboplatin/gemcitabine, an alternative therapy regimen

Lung Cancer - Lung cancer treated by irinotecan and cisplatin

Lung Cancer - Pharmacokinetics of amrubicin in lung cancer patients characterized

Lung Cancer - Quinuclidinone analogs examined as anti-proliferative agents in lung cancer

Lung Cancer - Reports describe recent advances in lung cancer research

Lung Cancer - Resected non-small cell lung cancer linked to extreme chemotherapy resistance

Malaria Vaccines - New findings in the area of malaria vaccines described

Marketing - Sinovac, LG Life Sciences sign agreement to market hepatitis B vaccine in China

Melanoma - Impact of lymphoscintigraphy technique on outcome of sentinel node biopsy in melanoma discussed

Melanoma Vaccines - New data illuminates research in melanoma vaccines

Melanoma Vaccines - Recent studies add new data to melanoma vaccines research

Melanoma Vaccines - Reports add new data to melanoma vaccines research

Meningococcus Vaccine - Virulence is conserved in C to B capsule-switched Neisseria meningitidis

Methionine Kinetics - Methionine kinetics are altered in the elderly before and after vaccination

Myeloma - Outcome of myeloma not improved with addition of valspodar

Nephroblastoma - Wilms tumor complicated by liver metastases linked to less favorable outcome

Neuroscience - Neurotoxicity is attenuated by adenoviral gene transfer of superoxide dismutase

Ovarian Cancer - Mdr-1 polymorphism G2677T/A correlates with paclitaxel response in ovarian cancer

Personnel - Dr. Judith Hemberger joins ZymoGenetics board of directors

Personnel - Mark P. Backer, PhD, appointed president and CEO of West Coast Biologicals, Inc.

Personnel - MedImmune broadens management team with five additional leaders in key strategic areas

Personnel - Seattle Genetics appoints Dr. Daniel Hoth to board of directors

Pneumococcus Vaccine - Pneumococcal vaccination is unaffected by splenectomy

Pneumococcus Vaccine - T cell responses increase with age and determine antibody response and protective efficacy

Pneumonia - Contagious pleuropneumonia transmission and control has been modeled

Polio Vaccines - New findings in the area of polio vaccines described

Product Licensing - Norwood Abbey signs commercial-phase license agreement with MIT for needle-free injection system

Prostate Cancer - Cell Genesys to present data from two GVAX cancer immunotherapy clinical trials

Prostate Cancer - Hormone-sensitive prostate cancer treated with zoledronic acid therapy

SARS - SARS coronavirus triple-spanning membrane proteins are glycosylated

Smallpox Vaccine - Atopic dermatitis may lead to deadly complications from smallpox vaccine

Smallpox Vaccines - Recent findings illuminate research in smallpox vaccines

Smallpox Vaccines - Reports add new data to smallpox vaccines research

Soft Tissue Sarcomas - Soft tissue sarcoma should not be treated with gemcitabine as first-line chemotherapy

Stem Cell Research - Genetically corrected Fanconi anemia bone marrow cells can repopulate

Streptococcal Diseases -  Streptococcus equi SeM gene sequence variation discriminates outbreak source

Tissue Engineering - Tissue-engineered cartilage chondrocytes can be immortalized

Transitional Cell Carcinoma - Transitional cell carcinoma treated by gemcitabine and paclitaxel second-line chemotherapy

Tuberculosis Vaccine - Oral tuberculosis vaccine produced from a transgenic plant is immunogenic

Tumor Lysis Syndrome - Hyperuricemia corrected with reduced-dose rasburicase

Vaccinia Vaccine - Immune recognition by natural killer cells depends on cytotoxicity receptors

Vaccinia Virus - Vaccinia virus proteins have been identified in intracellular mature virion particles

Vector Development - Findings in vector development provide new insights

Vector Development - Recent findings in vector development provide new insights

Virology - Antibodies that ligate CD40 and OX40 have different effects

Virology - Immunocontraceptive effects are produced by a recombinant myxoma virus

Virology - Infectious bronchitis virus protein displays differences in localization and turnover

Virology - Metapneumovirus surface glycoproteins function in protective immunity

West Nile Virus - West Nile virus virulence in mice is attenuated by a single amino acid substitution

Yellow Fever Vaccine - Recombinant yellow fever 17D vaccine expresses Lassa virus glycoproteins

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