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Immunocontraceptive effects are produced by a recombinant myxoma virus

Published in Vaccine Weekly, April 12th, 2006

Recent research from Australia published in the journal Biology of Reproduction has documented immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3.

"Recombinant myxoma viruses expressing rabbit zona pellucida 2 (rZP2) or rabbit zona pellucida 3 (rZP3) glycoproteins were constructed and tested in domestic rabbits to assess their potential to induce autoimmune infertility," explained S.M. MacKenzie and colleagues of the Commonwealth Scientific and Industrial Research Organization.

"The recombinant virus expressing rZP2 had no effect on fertility or ovarian histology, despite all...

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