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Vaccine Delivery

Mucosal delivery of adjuvant-bound antigens is achieved using food-grade bacteria

Published in Vaccine Weekly, April 19th, 2006

A report from the Netherlands has described the mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria.

"Mucosal immunization with subunit vaccines requires new types of antigen delivery vehicles and adjuvants for optimal immune responses," wrote M.L. van Roosmalen and colleagues of BiOMaDe Technology Foundation.

"We have developed a non-living and non-genetically modified gram-positive bacterial delivery particle (GEM) that has built-in adjuvant activity and a high loading capacity for externally added heterologous antigens that are fused to a high affinity binding domain."

The...

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