Drug Delivery
Liposome delivery of model tumor antigen depends on type-1 interferons
Published in Vaccine Weekly, April 26th, 2006
"We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice," wrote D. Wakita and colleagues, Hokkaido University.
"C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7-8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining lymph node (DLN) with liposomes encapsulated with unmethylated cytosine-phosphorothioate-guanine containing oligodeoxynucleotides (CpG-ODN) (CpG-liposomes) co-encapsulated with...
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Source: Vaccine Weekly (2006-04-26)
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