Ovarian Cancer

TNF-alpha expression is regulated differently in normal and malignant ovarian epithelium

Published in Vaccine Weekly, May 3rd, 2006

Expression of tumor necrosis factor alpha (TNF-alpha) is differentially regulated in normal and malignant ovarian epithelium

According to a study from England, "Epidemiologic studies implicate inflammatory stimuli in the development of ovarian cancer. The proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and both its receptors ITNFRI and TNFRII) are expressed in biopsies of this malignancy. We tested the hypothesis that TNF-alpha is a regulator of the proinflammatory microenvironment of ovarian cancer."

"A cancer profiling array showed higher expression of TNF-alpha in ovarian tumors compared with normal ovarian tissue, and cultured...

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Source: Vaccine Weekly (2006-05-03)

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