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Anthrax Vaccine Development
Anthrax protective antigen 2 beta(2)-2 beta(3) loop has dominant neutralizing epitope
May 10th, 2006
The anthrax protective antigen 2 beta(2)-2 beta(3) loop contains a dominant neutralizing epitope. According to recent research from the People's Republic of China, "Anthrax toxin consists of three proteins, protective antigen (PA), lethal factor, and edema factor. PA is the major component in the current anthrax vaccine, but the antigenic epitopes on it are not well-defined." "We generated a pool of toxin-neutralizing anti-PA monoclonal antibodies (MAbs) to analyze the neutralizing epitopes of PA. Nine toxin-neutralizing MAbs obtained were found bound to three different domains of PA respectively, among which three MAbs with the strongest...
Source: Vaccine Weekly (2006-05-10)
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