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Cancer Gene Therapy



Gene-based vaccination produces immune responses against PSMA



May 10th, 2006

According to recent research from the United States published in the journal Cancer Gene Therapy, gene-based vaccination produces immune responses against prostate-specific membrane antigen (PSMA).

"Two plasmid DNA vaccines, encoding either products that are retained in the cytosol and degraded in the proteasome (tVacs; hPSMAt), or secreted proteins (sVacs; hPSMAs) were evaluated for stimulation of cytotoxic cell or antibody responses," wrote M. Mincheff and colleagues, George Washington University.

"Immunization with both vectors led to generation of cell cytotoxicity providing granulocyte-macrophage colony-stimulating factor was administered...


Source: Vaccine Weekly (2006-05-10)

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