Published in Vaccine Weekly, May 10th, 2006
Study 1: Fully human monoclonal antibodies to hepatocyte growth factor show therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.
"e-Met is a well-characterized receptor tyrosine kinase for hepatocyte growth factor (HGF). Compelling evidence from studies in human tumors and both cellular and animal tumor models indicates that signaling through the HGF/c-Met pathway mediates a plethora of normal cellular activities, including proliferation, survival, migration, and invasion, that are at the root of cancer cell dysregulation, tumorigenesis, and tumor...
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Source: Vaccine Weekly (2006-05-10)
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