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HIV/AIDS Vaccine
Robust HIV-specific immune responses were induced by DNA vaccine plus vaccinia virus boost
May 10th, 2006
Robust HIV-specific immune responses were induced by DNA vaccine prime followed by attenuated recombinant vaccinia virus (LC16m8 strain) boost.
"Recombinant vaccinia virus-based vaccine combined with DNA vaccine has produced a protective immune response against HIV infection in non-human primates. In this study, we explored the immunogenicity of a recombinant vaccinia virus (LC16m8 strain), which has been used in children without severe side effects," scientists in Japan report.
"The vaccinia virus expressing an HIV89.6 env gene (vLC-Env) atone or combined with a DNA vaccine expressing the HIV89.6 env gene (pCAG-Env) was characterized in...
Source: Vaccine Weekly (2006-05-10)
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