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Cancer Vaccine
Direct lentiviral vector administration induces antitumor immunity
May 10th, 2006
Direct in vivo administration of lentiviral vectors induced effective therapeutic antitumor immunity. According to recent research from Belgium, "Ex vivo lentivirally transduced dendritic cells (DC) have been described to induce CD8+ and CD4+ T-cell responses against various tumor-associated antigens (TAAs) in vitro and in vivo. We report that direct administration of ovalbumin (OVA) encoding lentiviral vectors caused in vivo transduction of cells that were found in draining lymph nodes (LNs) and induced potent anti-OVA cytotoxic T cells similar to those elicited by ex vivo transduced DC." "The cytotoxic T-lymphocyte (CTL) response following direct...
Source: Vaccine Weekly (2006-05-10)
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