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DNA Vaccine
Canine IL-12 fused heterodimeric DNA enhances type 1 cytokine response
May 10th, 2006
Expression of a canine interleukin (IL)-12 fused heterodimeric DNA selectively enhanced the type 1 cytokine response. According to a study from the United States, "Interleukin-12 (IL-12) is a heterodimeric cytokine that is a principal mediator of the innate immune response and modulator of acquired cell-mediated immunity. Administration of exogenous IL-12 can direct the host adaptive T cell response toward a type I phenotype. The co-administration of IL-12 with vaccine antigen, has been shown to augment the vaccine-induced Th1 response and protection against intracellular pathogens." "We show [in our report] that a canine IL-12 DNA, constructed by...
Source: Vaccine Weekly (2006-05-10)
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