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Drug Development
Adenoviral vectors with subgroup B and D fibers improve gene delivery to intestinal mucosa
May 10th, 2006
Adenoviral vectors bearing subgroup B and D fibers improve gene delivery to intestinal mucosa. According to recent research published in the Journal of Virology, "A major obstacle to successful oral vaccination is the lack of antigen delivery systems that are both safe and highly efficient. Conventional replication-incompetent adenoviral vectors, derived from human adenoviruses of subgroup C, are poorly efficient in delivering genetic material to differentiated intestinal epithelia. To date, 51 human adenovirus serotypes have been identified and shown to recognize different cellular receptors with different tissue distributions." "This natural...
Source: Vaccine Weekly (2006-05-10)
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