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Drug Resistance
Multidrug resistance in cancer targeted with newly developed drugs
May 10th, 2006
Targeting multidrug resistance in cancer was discussed. According to recent research from the United States, "Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In most cases, multiple drugs are used, as resistance to single agents occurs almost universally. For this reason, elucidation of mechanisms that confer simultaneous resistance to different drugs with different targets and chemical structures - multidrug resistance - has been a major goal of cancer biologists during the past 35 years." "Here, we review the most common of these mechanisms, one that relies on drug efflux from cancer cells mediated by...
Source: Vaccine Weekly (2006-05-10)
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