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Vaccinia Virus Vaccine
Vaccinia virus mutated in envelope proteins A33R and B5R are immunogenic
May 10th, 2006
Vaccinia viruses mutated in the viral envelope proteins A33R and B5R were immunogenic in mice. "The pathogenicity and immunogenicity in mice of WR.c1 and WR.c3, two mutants of the Western Reserve (WR) strain of vaccinia virus, mutated in the A33R and B5R proteins of the outer envelope of the virus, respectively, were studied," investigators in Israel report. "WR.c1 was the most attenuated virus, WR.c3 was somewhat more pathogenic, while WR was the most virulent of the three," said Irina Gurt and colleagues at Hebrew University. "While the WR and the WR.c3 viruses, intranasally inoculated into mice, spread efficiently to the different internal organs...
Source: Vaccine Weekly (2006-05-10)
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