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Allergy & Immunology
IgG binding plant N-glycans were generated in rabbits but not in mice
May 10th, 2006
Immunoglobulin G specifically binding plant N-glycans with high affinity could be generated in rabbits but not in mice. "Xylosylated and core alpha 1,3-fucosylated N-glycans from plants are immunogenic, and they play a still obscure role in allergy and in the field of plant-made protein pharmaceuticals. We immunized mice to generate monoclonal antibodies (mAbs) binding plant N-glycans specifically via the epitope containing either the xylose or the core alpha 1,3-fucose residue," scientists in Austria report. "Splenocytes expressing N-glycan-specific antibodies derived from C57BL/6 mice previously immunized with plant glycoproteins were preselected...
Source: Vaccine Weekly (2006-05-10)
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