Carcinogenesis
Anti-proliferative effect of COX inhibitors appears independent of COX-2 inhibition
Published in Vaccine Weekly, May 17th, 2006
"Considering possible tumorigenic activity of COX isozymes in myeloma, we examined expression levels of COX-1 and -2 in 7 human myeloma cell lines (ARH-77, IM-9, RPMI-8226, HPC, HS-Sultan, TSPC-1, and U-266). As analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR), all the cell lines constitutively expressed COX-1, while COX-2 levels markedly varied among different cell lines. Induction of COX-2 by phorbol ester was observed in RPMI-8226 and HPC cells," scientists in Japan reported.
"In contrast, COX-2 was constitutively...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
Source: Vaccine Weekly (2006-05-17)
More Articles from Vaccine Weekly
- Anthrax Vaccine
Recombinant Bacillus anthracis protective antigen protects against inhalational challenge - Glioblastoma Multiforme
Study finds novel vaccine curbs brain tumor growth, increases survival - Hepatitis B Vaccine
Translocation motif of hepatitis B virus improves protein vaccination - Marburg Virus
Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus - Shigellosis Vaccine
Shigella flexneri 2a and S. sonnei bivalent invasin complex vaccine is developed - Anthrax
Studies from the United States and India advance knowledge in anthrax research - More from this issue of Vaccine Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
