Published in Vaccine Weekly, May 17th, 2006
"Considering possible tumorigenic activity of COX isozymes in myeloma, we examined expression levels of COX-1 and -2 in 7 human myeloma cell lines (ARH-77, IM-9, RPMI-8226, HPC, HS-Sultan, TSPC-1, and U-266). As analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR), all the cell lines constitutively expressed COX-1, while COX-2 levels markedly varied among different cell lines. Induction of COX-2 by phorbol ester was observed in RPMI-8226 and HPC cells," scientists in Japan reported.
"In contrast, COX-2 was constitutively...
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