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Shigellosis Vaccine

 Shigella flexneri 2a and S. sonnei bivalent invasin complex vaccine is developed

Published in Vaccine Weekly, May 17th, 2006

Scientists have developed a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine.

According to recent research from the United States, "Over 160 million cases of shigellosis occur annually worldwide, with the two most prevalent species being Shigella flexneri and S. sonnei. Protective immunity against Shigella infection is primarily directed at the lipopolysaccharide (LPS) of the homologous serotype, so it may be necessary to combine monovalent vaccines for multiple Shigella serotypes to construct a multivalent vaccine against predominant serotypes."

"Recently, we described a subcellular...

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