Gene Research
TNF-alpha induces UPase gene expression and enhances cell sensitivity to 5'-DFUR
Published in Vaccine Weekly, May 24th, 2006
"UPase has been shown to play an important role in the antineoplastic activity of 5-fluorouracil (5-FU) and in the anabolism of its oral prodrug, capecitabine, through the conversion of 5'-DFUR into 5-FU. In this study, we investigated the effect of tumor necrosis factor-alpha (TNF-alpha) on UPase gene expression and 5'-DFUR antiproliferative activity and elucidated the involved signal transduction pathway," scientists in the United States reported.
"Our data indicate that TNF-alpha significantly induced UPase mRNA...
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Source: Vaccine Weekly (2006-05-24)
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