Published in Vaccine Weekly, May 31st, 2006
"CD4+CD25+ T-regulatory cells (Treg ) can inhibit the proliferation and cytokine secretion of CD4+CD25- helper T cells in mice and humans. In murine tumor models, the presence of these Treg cells can inhibit the antitumor effectiveness of T-cell transfer and active immunization approaches. We have thus initiated efforts to eliminate Treg cells selectively from human peripheral blood mononuclear cells (PBMCs) to potentially bolster...
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