Published in Vaccine Weekly, May 31st, 2006
According to researchers in the United States, "The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA). Expression of HgbA is necessary for H. ducreyi to survive and initiate disease in a human model of chancroid."
"In this study, we used a swine model of H. ducreyi infection to demonstrate that an experimental HgbA vaccine...
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