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Chancroid Vaccine

 Haemophilus ducreyi hemoglobin receptor protects against chancroid

Published in Vaccine Weekly, May 31st, 2006

Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid.

According to researchers in the United States, "The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA). Expression of HgbA is necessary for H. ducreyi to survive and initiate disease in a human model of chancroid."

"In this study, we used a swine model of H. ducreyi infection to demonstrate that an experimental HgbA vaccine...

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