Gene Therapy
Protocol to monitor toxicity of lipid-mediated gene transfer has been developed
Published in Vaccine Weekly, June 7th, 2006
According to recent research published in the journal Basic and Clinical Pharmacology and Toxicology, "Adverse effects of cDNA and oligonucleotide delivery methods have not yet been systematically analyzed. We introduce a protocol to monitor toxic effects of two non-viral lipid-based gene delivery protocols using CNS primary tissue."
"Cell membrane damage was monitored by quantifying cellular uptake of propidium iodide and release of cytosolic lactate dehydrogenase to the culture medium," explained...
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Source: Vaccine Weekly (2006-06-07)
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