Polyomavirus Vaccine
Antibodies recognizing polyomavirus JC virus large T antigen have been characterized
Published in Vaccine Weekly, June 7th, 2006
According to a study from Japan, "Polyomavirus JC virus (JCV) is the causative agent of progressive multifocal leukoencephalopathy, a fatal demyelinating disease of the central nervous system. Similar to other polyomaviruses, such as simian vacuolating virus 40 (SV40) and BK virus (BKV), JCV is also associated with human tumors."
"The polyomavirus early protein large T antigen (TAg) plays a crucial role in tumor pathogenesis. An antibody to SV40 TAg (PAb416), which cross-reacts with TAgs...
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Source: Vaccine Weekly (2006-06-07)
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