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Virology

Distribution of rotavirus proteins in insect cell-baculovirus system is described

Published in Vaccine Weekly, June 7th, 2006

Scientists report the intracellular distribution of rotavirus structural proteins and virus-like particles expressed in the insect cell-baculovirus system in a recent issue of the Journal of Biotechnology.

According to their report, "The production of virus-like particles (VLP) is of interest to several fields. However, little is known about their assembly when they are expressed in insect cells, as it occurs in conditions different to those of native virus. Knowledge of the localization of recombinant proteins and of the site of accumulation of VLP can increase the understanding of VLP assembly and be useful for proposing production strategies."

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