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Vaccine Development

Anti-TNF antibodies are the focus of review

Published in Vaccine Weekly, June 14th, 2006

Antitumor necrosis factor (TNF) antibodies are reviewed in a recent issue of the Revue Francaise D Allergologie Et D'Immunologie Clinique.

According to the review, "TNF-alpha is a pivotal cytokine with pleiotropic effects in the innate and adaptive immune systems. Clinically, two strategies have been developed to neutralize it: monoclonal anti-TNF-alpha antibodies and a recombinant protein containing the p75 receptor."

Thierry Martin at INSERM U737 in Strasbourg wrote, "These products have been shown to be remarkably efficacious in the treatment of certain autoimmune and inflammatory conditions, in particular, in rheumatoid arthritis,...

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