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Alzheimer Disease Vaccine

Effects of immunization with A-beta1-42 in canines were characterized

Published in Vaccine Weekly, June 14th, 2006

Researchers characterize the effects of immunization with fibrillar A-beta1-42 in young and aged canines in a recent issue of Vaccine.

According to their report from the United States, "We describe a study testing fibrillar beta-amyloid1-42 (A-beta42 ) vaccination in dogs.

"Three young beagles (4.6 years) were immunized twice with A-beta42 and a Th1 adjuvant (TiterMax Gold)," explained Elizabeth Head at the University of California-Irvine and collaborators. "Animals generated primarily IgG2 and IgM antibody responses, which were specific for the A-beta11-30 region of...

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