Vaccine Development
Oil adjuvants are making a comeback in therapeutic vaccines
Published in Vaccine Weekly, June 21st, 2006
According to a report from France, "Water-in-oil emulsions represent one of the new promising generations of adjuvants for immunotherapy. Fifty years ago, incomplete Freund adjuvant (IFA) was used in clinical trials for prophylactic vaccines such as poliomyelitis or influenza vaccine because of its strong potency. However, even if the quality of the raw materials has been improved to avoid secondary reactions, the risk-benefit ratio was not favorable to its use for prophylactic vaccines. Moreover, emulsions were highly viscous with poor stability."
"The development of new adjuvants concepts...
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Source: Vaccine Weekly (2006-06-21)
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