Cancer Vaccine
Loss-of-function RNA interference screen is developed to identify cancer targets
Published in Vaccine Weekly, June 21st, 2006
"The pursuit of novel therapeutic agents in cancer relies on the identification and validation of molecular targets. Hallmarks of cancer include self-sufficiency in growth signals and evasion from apoptosis; genes that regulate these processes may be optimal for therapeutic attack. Here we describe a loss-of-function screen for genes required for the proliferation and survival of cancer cells using an RNA interference library. We used a doxycycline-inducible retroviral vector for the expression of small hairpin RNAs (shRNAs) to construct a library targeting...
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Source: Vaccine Weekly (2006-06-21)
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