Immunotherapy
CpG oligodeoxynucleotides promote innate mucosal immunity
Published in Vaccine Weekly, June 21st, 2006
According to recent research from Sweden, "The recent discovery of pathogen-associated molecular patterns (PAMPs) as potential ligands for the evolutionary conserved innate immune receptors termed Toll-like receptors has enabled a modern era of immunotherapy using synthetic mimics of pathogen molecules. Among the PAMPs, bacterial DNA or synthetic oligodeoxynucleotides (ODNs) that contain unmethylated CpG motif shows promising effect on activation of systemic innate immune response."
"We could document that CpG ODN is capable of mobilizing a potent innate immunity in the mucosal tissues," said...
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Source: Vaccine Weekly (2006-06-21)
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