Published in Vaccine Weekly, June 28th, 2006
Study 1: Vaccinia viruses mutated in the viral envelope proteins A33R and B5R were immunogenic in mice.
"The pathogenicity and immunogenicity in mice of WR.c1 and WR.c3, two mutants of the Western Reserve (WR) strain of vaccinia virus, mutated in the A33R and B5R proteins of the outer envelope of the virus, respectively, were studied," investigators in Israel report.
"WR.c1 was the most attenuated virus, WR.c3 was somewhat more pathogenic, while WR was the most virulent of the three," said Irina Gurt and colleagues at Hebrew University....
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Source: Vaccine Weekly (2006-06-28)
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