Hepatocellular Cancer Vaccine
Dendritic cells pulsed with alpha-fetoprotein peptides (AFP) elicit AFP-specific T cells
Published in Vaccine Weekly, July 5th, 2006
According to a study from the United States, "Alpha-fetoprotein (AFP) is a self protein expressed by fetal liver at high levels, but is transcriptionally repressed at birth. AFP is up-regulated in hepatocellular carcinomas, and patients with active disease could have plasma levels as high as 1 mg/mL. We previously identified four immunodominant HLA-A*0201-restricted peptides [hAFP137-145 (PLFQVPEPV), hAFP158-166 (FMNKFIYEI), hAFP325-334 (GLSPNLNRFL), and hAFP542-550 (GVALQTMKQ)]...
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Source: Vaccine Weekly (2006-07-05)
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